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Comparison of platelets characteristics according to various processing methods
- Authors: Karpova O.V.1,2, Obraztsov I.V.1,2, Trakhtman P.E.1,2, Ignatova1 A.A.1,2, Panteleev M.A.1,3,4,5, Rumyantsev S.A.1,6,7,8
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Affiliations:
- Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow
- 1, Samory Mashela st., Moscow, Russia, 117198
- 1, Samory Mashela st., Moscow, Russia, 117198 Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow
- 4, Kosygina st., Moscow, Russia, 119991 M.V. Lomonosov Moscow State University
- 1, Leninskie gory, Moscow, Russia, 119991
- 1, Samory Mashela st., Moscow, Russia, 117198 N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow
- 1, Ostrovityanova st., Moscow, Russia, 117997 Moscow Institute of Physics and Technology State University
- 9, Institutskiy per., Dolgoprudnyi, Moscow Oblast, Russia, 141700
- Issue: Vol 9, No 4 (2014)
- Pages: 37-45
- Section: BASIC RESEARCH
- Published: 30.12.2014
- URL: https://oncohematology.abvpress.ru/ongm/article/view/130
- DOI: https://doi.org/10.17650/1818-8346-2014-9-4-37-45
- ID: 130
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Abstract
To date different techniques of platelet concentrates (PC) preparation and processing are proposed to achieve the best efficiency of transfusions and to minimize the risks post-transfusion reactions. However, data on the impact of different approaches to PC preparation and processing on morphological and functional characteristics of platelets and, as a consequence, the clinical efficacy of transfusions is controversial. In this paper we analyzed the impact of the platelet storage solution and different methods of pathogen inactivation (X-rays, UV-irradiation after photosensitization with riboflavin) on morphological and functional parameters of platelets. Our findings allow optimizing the technology of preparation and processing of PC to achieve greater effectiveness of transfusion therapy.
About the authors
O. V. Karpova
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198
Author for correspondence.
Russian Federation
I. V. Obraztsov
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Russian Federation
P. E. Trakhtman
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Russian Federation
A. A. Ignatova1
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Russian Federation
M. A. Panteleev
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198Theoretical Problems Center of Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow; 4, Kosygina st., Moscow, Russia, 119991
M.V. Lomonosov Moscow State University; 1, Leninskie gory, Moscow, Russia, 119991
Russian Federation
S. A. Rumyantsev
Federal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitriy Rogachev, Ministry of Health of Russia, Moscow; 1, Samory Mashela st., Moscow, Russia, 117198N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow; 1, Ostrovityanova st., Moscow, Russia, 117997
Moscow Institute of Physics and Technology State University; 9, Institutskiy per., Dolgoprudnyi, Moscow Oblast, Russia, 141700
Russian Federation
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