Basic mechanisms of iron metabolism regulation and their clinical significance

L. M. Meshсheryakova; Мещерякова Л. М.; A. A. Levina; Левина А. А.; M. M. Tsybulskaya; Цыбульская М. М.; T. V. Sokolova; Соколова Т. В.

doi:10.17650/1818-8346-2014-9-3-67-71

Basic mechanisms of iron metabolism regulation and their clinical significance

Authors: Meshсheryakova L.M.¹, Levina A.A.², Tsybulskaya M.M.², Sokolova T.V.²
Affiliations:
1. Hematologic Scientific Center, Ministry of Health of Russia, Moscow
2. Outpatient center “City polyclinic № 62”, Moscow Department of Health Care
Issue: Vol 9, No 3 (2014)
Pages: 67-71
Section: EDUCATIONAL LECTURES, REVIEWS
Published: 30.10.2014
URL: https://oncohematology.abvpress.ru/ongm/article/view/125
DOI: https://doi.org/10.17650/1818-8346-2014-9-3-67-71
ID: 125

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Abstract

This article is а composition of literature and experimental data of iron metabolism. There were studied the level of DMT-1, ferroportin, hepcidin at different stages of anemia and hemochromatosis. It is clear that the level of DMT-1 regulates by the hepcidin. Increaseing of the hepcidin concentration and decreasing DMT-1 level in patients with hemochromatosis explained good results of treatment.