Interim results of the Ph-negative acute lymphoblastic leukemia treatment in adult patients (results of Russian research group of ALL treatment (RALL))

E. N. Parovichnikova; Паровичникова Е. Н.; V. V. Troitskaya; Троицкая В. В.; A. N. Sokolov; Соколов А. Н.; Z. Kh. Akhmerzaeva; Ахмерзаева З. Х.; L. A. Kuzmina; Кузьмина Л. А.; L. P. Mendeleeva; Менделеева Л. П.; G. A. Klyasova; Клясова Г. А.; S. K. Kravchenko; Кравченко С. К.; Ye. O. Gribanova; Грибанова Е. О.; S. N. Bondarenko; Бондаренко С. Н.; O. Yu. Baranova; Баранова О. Ю.; T. S. Kaporskaya; Капорская Т. С.; T. V. Ryltsova; Рыльцова Т. В.; A. S. Nizamutdinova; Низамутдинова А. С.; T. P. Zagoskina; Загоскина Т. П.; Ye. Ye. Zinina; Зинина Е. Е.; O. S. Samoylova; Самойлова О. С.; A. V. Klimovich; Климович А. В.; Ye. A. Karyakina; Карякина Е. А.; A. S. Yelufer’eva; Елуферьева А. С.; L. V. Gavrilova; Гаврилова Л. В.; T. S. Konstantinova; Константинова Т. С.; I. Yu. Toropova; Торопова И. Ю.; A. S. Pristupa; Приступа А. С.; N. A. Vopilina; Вопилина Н. А.; T. S. Tikunova; Тикунова Т. С.; O. P. Skamorina; Скаморина О. П.; K. D. Kaplanov; Капланов К. Д.; T. N. Obukhova; Обухова Т. Н.; I. V. Galtseva; Гальцева И. В.; M. A. Rusinov; Русинов М. А.; S. M. Kulikov; Куликов С. М.; V. G. Savchenko; Савченко В. Г.

doi:10.17650/1818-8346-2014-9-3-6-15

Interim results of the Ph-negative acute lymphoblastic leukemia treatment in adult patients (results of Russian research group of ALL treatment (RALL))

Authors: Parovichnikova E.N.¹, Troitskaya V.V.¹, Sokolov A.N.¹, Akhmerzaeva Z.K.¹, Kuzmina L.A.¹, Mendeleeva L.P.¹, Klyasova G.A.¹, Kravchenko S.K.¹, Gribanova Y.O.¹, Bondarenko S.N.², Baranova O.Y.³, Kaporskaya T.S.⁴, Ryltsova T.V.⁵, Nizamutdinova A.S.⁶, Zagoskina T.P.⁷, Zinina Y.Y.⁸, Samoylova O.S.⁹, Klimovich A.V.¹⁰, Karyakina Y.A.¹¹, Yelufer’eva A.S.¹², Gavrilova L.V.¹³, Konstantinova T.S.¹⁴, Toropova I.Y.¹⁵, Pristupa A.S.¹⁶, Vopilina N.A.¹⁷, Tikunova T.S.¹⁸, Skamorina O.P.¹⁹, Kaplanov K.D.²⁰, Obukhova T.N.¹, Galtseva I.V.¹, Rusinov M.A.¹, Kulikov S.M.¹, Savchenko V.G.¹
Affiliations:
1. Hematologic Scientific Center, Ministry of Health of Russia, Moscow
2. Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
3. N.N. Blokhin Russian Cancer Research Center, Moscow
4. Irkutsk Regional Hospital
5. Tula Regional Hospital
6. Municipal Alexander Hospital, St.-Petersburg
7. Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency
8. Surgut Regional Hospital
9. N.A. Semashko Regional Clinical Hospital, N. Novgorod
10. City Clinical Hospital ‡‚ 31, St..Petersburg
11. City Hospital № 15, St.‑Petersburg
12. M.I. Kalinin Regional Clinical Hospital, Samara
13. Mordovian Republican Clinical Hospital, Saransk
14. Regional Hematology Center, Sverdlovsk Regional Clinical Hospital № 1, Yekaterinburg
15. Regional Clinical Hospital, Yaroslavl
16. Regional Clinical Hospital, Ryazan
17. V.D. Babenko Regional Clinical Hospital, Tambov
18. St. Ioasafa Belgorod Regional Hospital
19. Central Clinical Military Hospital, Federal Security Service of Russia, Moscow
20. Regional Clinical Oncology Dispensary № 1, Volgograd
Issue: Vol 9, No 3 (2014)
Pages: 6-15
Section: HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CARE
Published: 30.10.2014
URL: https://oncohematology.abvpress.ru/ongm/article/view/118
DOI: https://doi.org/10.17650/1818-8346-2014-9-3-6-15
ID: 118

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Abstract

An interim analysis of long-term treatment results for 202 patients with acute lymphoblastic leukemia (ALL), aged 15–60 years, received therapy according protocol ALL-2009 was shown. The basic principle of ALL-2009 was non-aggressive, but continued cytostatic exposure, as well as the reproducibility in a regional hematology centers. Long-term treatment results of ALL-2009 are 2 times higher than the previously obtained in adult ALL patients within the Russian clinical multicenter studies of adult ALL. The 5‑year overall survival of patients younger than 30 years was 73.6 %, relapse-free survival (RFS) – 71.5 %, compared with 52.7 % and 61.8 % in patients aged 30 years and older, respectively. In patients with B-precursor ALL with normal karyotype of blast cells significantly higher 5‑year RFS (82.1 %) compared to patients with abnormal karyotype (58.8 %) was registered. For T-ALL cytogenetic characteristics of blast cells had no prognostic significance. For patients with T-ALL important to perform autologous stem cell transplantation as a later consolidation, as this significantly reduce
relapse rate (from 33 to 0 %).

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acute lymphoblastic leukemia in adults, chromosomal abnormalities, autologous stem cell transplantation

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Interim results of the Ph-negative acute lymphoblastic leukemia treatment in adult patients (results of Russian research group of ALL treatment (RALL))

Full Text

Abstract

Keywords

About the authors

References

Supplementary files