Colistine pharmacokinetics and Colistimethate sodium daily dose calculation in children with chemotherapy induced neutropenia

A standard fractional Colistimethate sodium dosing regimen does not allow in most cases reach the target values of AUC / MIC index, determining the Colistine pharmacological efficacy. Use of the proposed algorithm for daily dose calculating increases the incidence to achieve Colistine concentration providing AUC values, sufficient for A. baumannii, P. aeruginosa and K. pneumoniae with Colistine MIC
0.75–1 mg / l. Using fractional administration of recommended daily dose target AUC values for MIC 1 g / l achieved only in 19 % cases,
whereas using the proposed algorithm of intravenous injection with long-time constant rate of daily dose 100.000 ME / kg Colistimethate
sodium – in 60 % (in 3 of 5 patients).