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Risk factors of CMV replication after allogeneic hematopoietic stem cell transplantation in children and adolescents
- Authors: Shiriaev S.N.1, Stancheva N.V.1, Morozova Y.V.1, Barkhatov I.M.1, Averianova M.Y.1, Razumova S.V.1, Goloshchapov O.V.1, Chukhlovin A.B.1, Zubarovskaya L.S.1, Afanasiev B.V.1
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Affiliations:
- Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
- Issue: Vol 9, No 2 (2014)
- Pages: 45-52
- Section: HEMATOPOIETIC STEM CELL TRANSPLANTATION
- Published: 17.09.2014
- URL: https://oncohematology.abvpress.ru/ongm/article/view/114
- DOI: https://doi.org/10.17650/1818-8346-2014-9-2-45-52
- ID: 114
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Abstract
Risk factors of CMV replication in early period after allo-HSCT (D0‑D100) were – myeloablative conditioning – HR 3.74 (1.67–8.37), р = 0.001; unrelated donor – HR 2.18 (0.86–5.26), р = 0.10; HLA-matched donor – HR 0.24 (0.05–1.06), р = 0,06. In late posttransplant period (from D+100) significant risk factors of CMV-reactivation were (according to multivariate analysis) myeloablative conditioning – HR 13.17 (3.00–57.86), р = 0.001; combination of pretransplant remission of leukemia and using cyclosporine and methotrexate – HR 0.13 (0.03–0.50), р = 0.003; combination of aGVHD and CMV reactivation in early posttransplant period – HR 2.71 (0.86–8.50), р = 0.088; using of bone marrow – HR 0.37 (0.12–1.19), р = 0.095. We revealed the significant association of aGVHD and CMV-reactivation –OR 2.91 (1.07–7.92), р=0.006, and increased rate of cGVHD in patients with CMV replication at third month after allo-HSCT OR – 2.29 (1.03–5.08), р = 0.066. We revealed a tend to decreasing relapse risk in patients who had CMV-replication – HR 0.07 (0.004–1.17), р = 0.06. Cumulative incidence of CMV-disease was 28 %. CMV-disease was lethal in 44 % patients.
About the authors
S. N. Shiriaev
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation,I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Author for correspondence.
Email: ftk9@yandex.ru
Russian Federation
N. V. Stancheva
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation,I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation
Ye. V. Morozova
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation,I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation
I. M. Barkhatov
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation,I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation
M. Yu. Averianova
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation,I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation
S. V. Razumova
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation,I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation
O. V. Goloshchapov
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation,I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation
A. B. Chukhlovin
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation,I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation
L. S. Zubarovskaya
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation,I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation
B. V. Afanasiev
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation,I. P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of Russia
Russian Federation
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