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Treatment of non-Hodgkin lymphoma and mature В-cell acute leukemia in children and adolescents: data of Russian regional hospitals
- Authors: Samochatova Y.V.1, Shelikhova L.N.2
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Affiliations:
- Federal Research Center of Pediatric Hematology, Oncology and Immunology
- Russian Children Clinical Hospital
- Issue: Vol 6, No 1 (2011)
- Pages: 30-34
- Section: HEMATOLOGIC MALIGNANCIES: DIAGNOSIS, TREATMENT, SUPPORTIVE CARE
- Published: 24.02.2011
- URL: https://oncohematology.abvpress.ru/ongm/article/view/102
- DOI: https://doi.org/10.17650/1818-8346-2011-6-1-30-34
- ID: 102
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Abstract
The article presents treatment results of 233 patients (children and adolescents under 19 years old; median — 8.76 years) with CD20-
positive non-Hodgkin lymphomas and B-cell acute leukemia (B-NHL/B-AL) received chemotherapy (BFM B-NHL 90–95 protocols) or combined chemo-immunotherapy with rituximab (B-NHL-2004mab protocol). Combined chemo-immunotherapy was used for patients with Burkitt lymphoma, diffuse large cells lymphomas stage III–IV and B-AL, and included cytoreductive phase, 6 polychemotherapy (PCT) courses and rituximab. PCT courses are similar to those of original BFM B-NHL90 protocol, except for the first 2 courses, where daily methotrexate dose was reduced from 5 to 1 g/m2/24 h. Rituximab infused IV 12 hours before the start of first 4 chemotherapy courses at a dose of 375 mg/m2. The data in the questionnaires form have been submitted from 28 pediatric specialized hospitals from 27 Russia regions over the past 5 years (2005–2009). Protocol with rituximab has proved to be more effective than chemotherapy alone. The authors discuss the possibility of using combined chemo-immunotherapy for the treatment of B-NHL/B-AL at regional hospitals and the prospects for further treatment results improvement in this group of tumors.
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About the authors
Ye. V. Samochatova
Federal Research Center of Pediatric Hematology, Oncology and Immunology
Author for correspondence.
Email: samochatova@niidg.ru
Russian Federation
L. N. Shelikhova
Russian Children Clinical HospitalRussian Federation
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