Burkitt lymphoma with heart involvement: features of diagnosis, treatment and follow-up

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Abstract

   Burkitt lymphoma (BL) is a highly aggressive non‑Hodgkin’s lymphoma that characterizes by affecting multiple organs and systems, which explains the diagnosis of the disease at an advanced stage upon the patient’s first medical visit. Heart involvement as part of bL dissemination is extremely rare (2–5 %), but significantly impacts the clinical course, treatment and follow‑up. Heart involvement in bL can manifest as pericardial effusion, myocardial dysfunction or subsequent development of cardiogenic shock. diagnostics of BL with heart involvement should include electrocardiography, echocardiography, N‑terminal fragment of the brain natriuretic propeptide (NT‑proBNP) blood level, myocardial damage markers (troponin I / T), and, if necessary, can include more high‑precision methods – magnetic resonance / computed tomography with intravenous contrast. Timely diagnosis and programmed treatment with rituximab can achieve long‑term survival for BL patients, including advanced stages with heart involvement.

About the authors

G. A. Radzhabova

Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia

ORCID iD: 0009-0008-8297-3629

125993; Build. 1, 2 / 1 Barrikadnaya St.; Moscow

Russian Federation

I. V. Osipova

Children’s Republican Clinical Hospital, Ministry of Health of the Republic of Tatarstan

420138; 140 Orenburgsky Tract St.; Kazan

Russian Federation

T. T. Valiev

Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia; N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Author for correspondence.
Email: timurvaliev@mail.ru
ORCID iD: 0000-0002-1469-2365

Timur Teymurazovich Valiev

125993; Build. 1, 2 / 1 Barrikadnaya St.; 155522; 24 Kashirskoe Shosse; 119991; Build. 2, 8 Trubetskaya St.; Moscow

Russian Federation

L. R. Turkiya

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

ORCID iD: 0009-0007-5457-6530

155522; 24 Kashirskoe Shosse; Moscow

Russian Federation

L. R. Karimova

Children’s Republican Clinical Hospital, Ministry of Health of the Republic of Tatarstan

420138; 140 Orenburgsky Tract St.; Kazan

Russian Federation

S. N. Mikhailova

N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia

155522; 24 Kashirskoe Shosse; Moscow

Russian Federation

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